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An unequal cross-over event within the CYP2D gene cluster generates a chimeric CYP2D7/CYP2D6 gene which is associated with the poor metabolizer phenotype.

1. The study of the CYP2D genotype and phenotype of a Caucasian family revealed that a XbaI-9 kb allele was associated with the poor metabolizer phenotype. 2. A Polymerase Chain Reaction (PCR)-based assay showed that the previously described mutations D6A and D6B are not associated with the XbaI-9 k...

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Main Authors: Panserat, S, Mura, C, Gérard, N, Vincent-Viry, M, Galteau, M M, Jacoz-Aigrain, E, Krishnamoorthy, R
格式: Artigo
語言:Inglês
出版: 1995
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC1365155/
https://ncbi.nlm.nih.gov/pubmed/8554938
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