An unequal cross-over event within the CYP2D gene cluster generates a chimeric CYP2D7/CYP2D6 gene which is associated with the poor metabolizer phenotype.

Eitemau Tebyg

• Molecular heterogeneity of the XbaI defined 44kb allele of the CYP2D locus within the Caucasian population.
  gan: Mura, C, et al.
  Cyhoeddwyd: (1993)
• CYP2D6 polymorphism in a Gabonese population: contribution of the CYP2D6*2and CYP2D6*17alleles to the high prevalence of the intermediate metabolic phenotype
  gan: Panserat, S, et al.
  Cyhoeddwyd: (1999)
• Study of CYP2D6 gene in children with autoimmune hepatitis and P450 IID6 autoantibodies.
  gan: Yamamoto, A M, et al.
  Cyhoeddwyd: (1992)
• Glucocorticoid-suppressible hyperaldosteronism results from hybrid genes created by unequal crossovers between CYP11B1 and CYP11B2.
  gan: Pascoe, L, et al.
  Cyhoeddwyd: (1992)
• NcoI RFLP in the pseudogene (CYP2D8P) of the human debrisoquine 4-hydroxylase locus
  gan: Mura, C., et al.
  Cyhoeddwyd: (1991)