Molecular heterogeneity of the XbaI defined 44kb allele of the CYP2D locus within the Caucasian population.

1. Cytochrome P450 debrisoquine (CYP2D6) activity is polymorphic and under genetic control. Most Caucasians are extensive metabolizers, but 5%-10% are poor metabolizers. 2. Restriction fragment length polymorphism analysis of the CYP2D6 locus identifies a 29kb XbaI fragment, either normal (D6-wt) or...

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Detalhes bibliográficos
Main Authors: Mura, C, Gerard, N, Vincent-Viry, M, Galteau, M M, Jacqz-Aigrain, E, Krishnamoorthy, R
Formato: Artigo
Idioma:Inglês
Publicado em: 1993
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1381508/
https://ncbi.nlm.nih.gov/pubmed/8095148
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