Pharmacokinetic and pharmacodynamic analysis of a novel leukotriene biosynthesis inhibitor, MK-0591, in healthy volunteers.

1. The pharmacokinetic and pharmacodynamic properties of a novel 2-indolealkanoic acid derivative (MK-0591), a potent inhibitor of leukotriene biosynthesis, were investigated in healthy male Japanese volunteers. Single oral doses of 50, 125, 250 and 500 mg and multiple oral doses of 125 mg twice dai...

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Main Authors: Uematsu, T, Kanamaru, M, Kosuge, K, Hara, K, Uchiyama, N, Takenaga, N, Tanaka, W, Friedman, B S, Nakashima, M
Formato: Artigo
Idioma:Inglês
Publicado: 1995
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1365028/
https://ncbi.nlm.nih.gov/pubmed/8527269
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