Pharmacokinetic and pharmacodynamic analysis of a novel leukotriene biosynthesis inhibitor, MK-0591, in healthy volunteers.

1. The pharmacokinetic and pharmacodynamic properties of a novel 2-indolealkanoic acid derivative (MK-0591), a potent inhibitor of leukotriene biosynthesis, were investigated in healthy male Japanese volunteers. Single oral doses of 50, 125, 250 and 500 mg and multiple oral doses of 125 mg twice dai...

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Autores principales: Uematsu, T, Kanamaru, M, Kosuge, K, Hara, K, Uchiyama, N, Takenaga, N, Tanaka, W, Friedman, B S, Nakashima, M
Formato: Artigo
Lenguaje:Inglês
Publicado: 1995
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1365028/
https://ncbi.nlm.nih.gov/pubmed/8527269
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