Inhibition of CYP2D6 activity by treatment with propranolol and the role of 4-hydroxy propranolol.

1. The 4-hydroxylation of propranolol by rat and human liver microsomes is associated with formation of a chemically reactive species which binds irreversibly to cytochrome P4502D6 (CYP2D6) destroying its catalytic function. Therefore, the effect of propranolol treatment (80 mg twice daily) on debri...

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Detalhes bibliográficos
Main Authors: Rowland, K, Yeo, W W, Ellis, S W, Chadwick, I G, Haq, I, Lennard, M S, Jackson, P R, Ramsay, L E, Tucker, G T
Formato: Artigo
Idioma:Inglês
Publicado em: 1994
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1364831/
https://ncbi.nlm.nih.gov/pubmed/7946944
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