The relationship between debrisoquine oxidation phenotype and the pharmacokinetics and pharmacodynamics of propranolol.

The pharmacokinetics and pharmacodynamics of propranolol (80 mg by mouth) were studied in seven extensive and four poor metabolisers of debrisoquine. Evidence for impairment of the 4'-hydroxylation of propranolol was found in poor metabolisers. However, no significant difference was detected in...

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Bibliografiske detaljer
Main Authors: Lennard, M S, Jackson, P R, Freestone, S, Tucker, G T, Ramsay, L E, Woods, H F
Format: Artigo
Sprog:Inglês
Udgivet: 1984
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1463425/
https://ncbi.nlm.nih.gov/pubmed/6743465
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