The relationship between debrisoquine oxidation phenotype and the pharmacokinetics and pharmacodynamics of propranolol.

The pharmacokinetics and pharmacodynamics of propranolol (80 mg by mouth) were studied in seven extensive and four poor metabolisers of debrisoquine. Evidence for impairment of the 4'-hydroxylation of propranolol was found in poor metabolisers. However, no significant difference was detected in...

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Библиографические подробности
Главные авторы: Lennard, M S, Jackson, P R, Freestone, S, Tucker, G T, Ramsay, L E, Woods, H F
Формат: Artigo
Язык:Inglês
Опубликовано: 1984
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC1463425/
https://ncbi.nlm.nih.gov/pubmed/6743465
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