A Single Amino Acid Mutation in the PA Subunit of the Influenza Virus RNA Polymerase Inhibits Endonucleolytic Cleavage of Capped RNAs

The influenza A virus RNA-dependent RNA polymerase consists of three subunits—PB1, PB2, and PA. The PB1 subunit is the catalytically active polymerase, catalyzing the sequential addition of nucleotides to the growing RNA chain. The PB2 subunit is a cap-binding protein that plays a role in initiation...

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Autores principales: Fodor, Ervin, Crow, Mandy, Mingay, Louise J., Deng, Tao, Sharps, Jane, Fechter, Pierre, Brownlee, George G.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2002
Materias:
Replication
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC136441/
https://ncbi.nlm.nih.gov/pubmed/12186883
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.76.18.8989-9001.2002
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