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Elimination of T-cell-receptor beta-chain diversity in transgenic mice restricts antigen-specific but not alloreactive responses.

The contribution of T-cell-receptor beta-chain diversity to the T-cell antigen-specific repertoire was investigated using single-chain T-cell-receptor transgenic mice. Animals that express the rearranged beta-chain gene from a T hybridoma with specificity for a hen egg lysozyme peptide, designated H...

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Autori principali: O'Brien, D P, Baecher-Allan, C M, Burns, R P, Shastri, N, Barth, R K
Natura: Artigo
Lingua:Inglês
Pubblicazione: 1997
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1364006/
https://ncbi.nlm.nih.gov/pubmed/9301526
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