A Single Mutation in the E2 Glycoprotein Important for Neurovirulence Influences Binding of Sindbis Virus to Neuroblastoma Cells

The amino acid at position 55 of the E2 glycoprotein (E2(55)) of Sindbis virus (SV) is a critical determinant of SV neurovirulence in mice. Recombinant virus strain TE (E2(55) = histidine) differs only at this position from virus strain 633 (E2(55)= glutamine), yet TE is considerably more neurovirul...

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Bibliografische Detailangaben

Veröffentlicht in:	J Virol
Hauptverfasser:	Lee, Peiyu, Knight, Ronald, Smit, Jolanda M., Wilschut, Jan, Griffin, Diane E.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 2002
Schlagworte:	Virus-Cell Interactions
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC136218/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12021363/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.76.12.6302-6310.2002
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