A Single Mutation in the E2 Glycoprotein Important for Neurovirulence Influences Binding of Sindbis Virus to Neuroblastoma Cells

The amino acid at position 55 of the E2 glycoprotein (E2(55)) of Sindbis virus (SV) is a critical determinant of SV neurovirulence in mice. Recombinant virus strain TE (E2(55) = histidine) differs only at this position from virus strain 633 (E2(55)= glutamine), yet TE is considerably more neurovirul...

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Pubblicato in:	J Virol
Autori principali:	Lee, Peiyu, Knight, Ronald, Smit, Jolanda M., Wilschut, Jan, Griffin, Diane E.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 2002
Soggetti:	Virus-Cell Interactions
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC136218/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12021363/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.76.12.6302-6310.2002
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