Laddar...
Binding of a novel SMG-1–Upf1–eRF1–eRF3 complex (SURF) to the exon junction complex triggers Upf1 phosphorylation and nonsense-mediated mRNA decay
Nonsense-mediated mRNA decay (NMD) is a surveillance mechanism that degrades mRNA containing premature termination codons (PTCs). In mammalian cells, recognition of PTCs requires translation and depends on the presence on the mRNA with the splicing-dependent exon junction complex (EJC). While it is...
Sparad:
| Huvudupphovsmän: | , , , , , , , , |
|---|---|
| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
Cold Spring Harbor Laboratory Press
2006
|
| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1361706/ https://ncbi.nlm.nih.gov/pubmed/16452507 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1389006 |
| Taggar: |
Lägg till en tagg
Inga taggar, Lägg till första taggen!
|