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Bioactive small molecules reveal antagonism between the integrated stress response and sterol-regulated gene expression
Phosphorylation of translation initiation factor 2α (eIF2α ) coordinates a translational and transcriptional program known as the integrated stress response (ISR), which adapts cells to endoplasmic reticulum (ER) stress. A screen for small molecule activators of the ISR identified two related compou...
Wedi'i Gadw mewn:
Prif Awduron: | , , , , , , , , |
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Fformat: | Artigo |
Iaith: | Inglês |
Cyhoeddwyd: |
2005
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Pynciau: | |
Mynediad Ar-lein: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1361344/ https://ncbi.nlm.nih.gov/pubmed/16330322 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2005.11.005 |
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