Mutations That Confer Resistance to Template-Analog Inhibitors of Human Immunodeficiency Virus (HIV) Type 1 Reverse Transcriptase Lead to Severe Defects in HIV Replication

We isolated two template analog reverse transcriptase (RT) inhibitor-resistant mutants of human immunodeficiency virus (HIV) type 1 RT by using the DNA aptamer, RT1t49. The mutations associated, N255D or N265D, displayed low-level resistance to RT1t49, while high-level resistance could be observed w...

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Pubblicato in:	J Virol
Autori principali:	Fisher, Timothy S., Joshi, Pheroze, Prasad, Vinayaka R.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 2002
Soggetti:	Vaccines and Antiviral Agents
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC136095/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11907245/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.76.8.4068-4072.2002
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