Mutations That Confer Resistance to Template-Analog Inhibitors of Human Immunodeficiency Virus (HIV) Type 1 Reverse Transcriptase Lead to Severe Defects in HIV Replication

We isolated two template analog reverse transcriptase (RT) inhibitor-resistant mutants of human immunodeficiency virus (HIV) type 1 RT by using the DNA aptamer, RT1t49. The mutations associated, N255D or N265D, displayed low-level resistance to RT1t49, while high-level resistance could be observed w...

Description complète

Détails bibliographiques

Publié dans:	J Virol
Auteurs principaux:	Fisher, Timothy S., Joshi, Pheroze, Prasad, Vinayaka R.
Format:	Artigo
Langue:	Inglês
Publié:	American Society for Microbiology (ASM) 2002
Sujets:	Vaccines and Antiviral Agents
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC136095/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11907245/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.76.8.4068-4072.2002
Tags:	Ajouter un tag Pas de tags, Soyez le premier à ajouter un tag!