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Structure-Based Optimization of a Non-β-lactam Lead Results in Inhibitors That Do Not Up-Regulate β-Lactamase Expression in Cell Culture
Bacterial expression of β-lactamases is the most widespread resistance mechanism to β-lactam antibiotics, such as penicillins and cephalosporins. There is a pressing need for novel, non-β-lactam inhibitors of these enzymes. One previously discovered novel inhibitor of the β-lactamase AmpC, compound...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2005
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1360654/ https://ncbi.nlm.nih.gov/pubmed/15796528 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja042984o |
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