Enhancing the Proteolytic Maturation of Human Immunodeficiency Virus Type 1 Envelope Glycoproteins

In virus-infected cells, the envelope glycoprotein (Env) precursor, gp160, of human immunodeficiency virus type 1 is cleaved by cellular proteases into a fusion-competent gp120-gp41 heterodimer in which the two subunits are noncovalently associated. However, cleavage can be inefficient when recombin...

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Main Authors: Binley, James M., Sanders, Rogier W., Master, Aditi, Cayanan, Charmagne S., Wiley, Cheryl L., Schiffner, Linnea, Travis, Bruce, Kuhmann, Shawn, Burton, Dennis R., Hu, Shiu-Lok, Olson, William C., Moore, John P.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2002
Teme:
Vaccines and Antiviral Agents
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC135977/
https://ncbi.nlm.nih.gov/pubmed/11861826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.76.6.2606-2616.2002
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