Truncation of the Cytoplasmic Domain Induces Exposure of Conserved Regions in the Ectodomain of Human Immunodeficiency Virus Type 1 Envelope Protein

We have described a CD4-independent variant of HXBc2, termed 8x, that binds directly to CXCR4 and mediates CD4-independent virus infection. Determinants for CD4 independence map to residues in the V3 and V4-C4 domains together with a single nucleotide deletion in the transmembrane domain which intro...

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Bibliographic Details
Main Authors: Edwards, Terri G., Wyss, Stéphanie, Reeves, Jacqueline D., Zolla-Pazner, Susan, Hoxie, James A., Doms, Robert W., Baribaud, Frédéric
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2002
Subjects:
Pathogenesis and Immunity
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC135967/
https://ncbi.nlm.nih.gov/pubmed/11861835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.76.6.2683-2691.2002
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