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Drusen deposits associated with aging and age-related macular degeneration contain nonfibrillar amyloid oligomers

Protein misfolding and aggregation are thought to underlie the pathogenesis of many amyloid diseases, such as Alzheimer and Parkinson diseases, whereby a stepwise protein misfolding process begins with the conversion of soluble protein monomers to prefibrillar oligomers and progresses to the formati...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Luibl, Volker, Isas, Jose M., Kayed, Rakez, Glabe, Charles G., Langen, Ralf, Chen, Jeannie
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Clinical Investigation 2006
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC1359048/
https://ncbi.nlm.nih.gov/pubmed/16453022
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI25843
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