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Drusen deposits associated with aging and age-related macular degeneration contain nonfibrillar amyloid oligomers
Protein misfolding and aggregation are thought to underlie the pathogenesis of many amyloid diseases, such as Alzheimer and Parkinson diseases, whereby a stepwise protein misfolding process begins with the conversion of soluble protein monomers to prefibrillar oligomers and progresses to the formati...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical Investigation
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1359048/ https://ncbi.nlm.nih.gov/pubmed/16453022 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI25843 |
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