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Novel Design Architecture for Genetic Stability of Recombinant Poliovirus: the Manipulation of G/C Contents and Their Distribution Patterns Increases the Genetic Stability of Inserts in a Poliovirus-Based RPS-Vax Vector System

Poliovirus has been studied as a live recombinant vaccine vector because of its attractive characteristics. The genetic instability, however, has hampered recombinant polioviruses (PVs) from being developed as an appropriate vaccine. A variety of different foreign inserts were cloned directly into o...

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Detalhes bibliográficos
Main Authors: Lee, Sang-Gu, Kim, Dae-You, Hyun, Byung-Hwa, Bae, Yong-Soo
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2002
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC135903/
https://ncbi.nlm.nih.gov/pubmed/11799160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.76.4.1649-1662.2002
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