Antigenic Evolution of Vaccine-Derived Polioviruses: Changes in Individual Epitopes and Relative Stability of the Overall Immunological Properties

The Sabin oral poliovirus vaccine (OPV) readily undergoes changes in antigenic sites upon replication in humans. Here, a set of antigenically altered descendants of the three OPV serotypes (76 isolates) was characterized to determine the driving forces behind these changes and their biological impli...

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Detalhes bibliográficos
Main Authors: Yakovenko, Maria L., Cherkasova, Elena A., Rezapkin, Gennady V., Ivanova, Olga E., Ivanov, Alexander P., Eremeeva, Tatyana P., Baykova, Olga Y., Chumakov, Konstantin M., Agol, Vadim I.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2006
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1395452/
https://ncbi.nlm.nih.gov/pubmed/16501074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.80.6.2641-2653.2006
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