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Chimpanzee-Human Monoclonal Antibodies for Treatment of Chronic Poliovirus Excretors and Emergency Postexposure Prophylaxis

Six poliovirus-neutralizing Fabs were recovered from a combinatorial Fab phage display library constructed from bone marrow-derived lymphocytes of immunized chimpanzees. The chimeric chimpanzee-human full-length IgGs (hereinafter called monoclonal antibodies [MAbs]) were generated by combining a chi...

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Detalhes bibliográficos
Main Authors: Chen, Zhaochun, Chumakov, Konstantin, Dragunsky, Eugenia, Kouiavskaia, Diana, Makiya, Michelle, Neverov, Alexander, Rezapkin, Gennady, Sebrell, Andrew, Purcell, Robert
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3126281/
https://ncbi.nlm.nih.gov/pubmed/21345966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02553-10
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