Evolution of the Sabin Vaccine into Pathogenic Derivatives without Appreciable Changes in Antigenic Properties: Need for Improvement of Current Poliovirus Surveillance

The Sabin oral polio vaccine (OPV) may evolve into pathogenic viruses, causing sporadic cases and outbreaks of poliomyelitis. Such vaccine-derived polioviruses (VDPV) generally exhibit altered antigenicity. The current paradigm to distinguish VDPV from OPV and wild polioviruses is to characterize pr...

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Autores principales: Yakovenko, Maria L., Korotkova, Ekaterina A., Ivanova, Olga E., Eremeeva, Tatyana P., Samoilovich, Elena, Uhova, Iryna, Gavrilin, Gene V., Agol, Vadim I.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology (ASM) 2009
Materias:
Vaccines and Antiviral Agents
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2655595/
https://ncbi.nlm.nih.gov/pubmed/19129444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02122-08
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