Genetic Stability of Parainfluenza Virus 5-Vectored Human Respiratory Syncytial Virus Vaccine Candidates after In Vitro and In Vivo Passage

Human respiratory syncytial virus (RSV) is the leading etiologic agent of lower respiratory tract infections in children, but no licensed vaccine exists. Previously, we developed two parainfluenza virus 5 (PIV5)-based RSV vaccine candidates that protect mice against RSV challenge. PIV5 was engineere...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Phan, Shannon I., Adam, Carolyn M., Chen, Zhenhai, Citron, Michael, Liang, Xiaoping, Espeseth, Amy S., Wang, Dai, He, Biao
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2017
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5599752/
https://ncbi.nlm.nih.gov/pubmed/28747497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00559-17
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