Probing the Sialic Acid Binding Site of the Hemagglutinin-Neuraminidase of Newcastle Disease Virus: Identification of Key Amino Acids Involved in Cell Binding, Catalysis, and Fusion

We recently reported the first crystal structure of a paramyxovirus hemagglutinin-neuraminidase (HN) from Newcastle disease virus. This multifunctional protein is responsible for binding to cellular sialyl-glycoconjugate receptors, promotion of fusion through interaction with the second viral surfac...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Connaris, Helen, Takimoto, Toru, Russell, Rupert, Crennell, Susan, Moustafa, Ibrahim, Portner, Allen, Taylor, Garry
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2002
Schlagworte:
Virus-Cell Interactions
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC135884/
https://ncbi.nlm.nih.gov/pubmed/11799177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.76.4.1816-1824.2002
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