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Mutations in the Cytoplasmic Domain of a Paramyxovirus Fusion Glycoprotein Rescue Syncytium Formation and Eliminate the Hemagglutinin-Neuraminidase Protein Requirement for Membrane Fusion

SER virus is closely related to the paramyxovirus simian virus 5 (SV5) but is defective in syncytium formation. The SER virus F protein has a long cytoplasmic tail (CT) domain that has been shown to inhibit membrane fusion, and this inhibitory effect could be eliminated by truncation of the C-termin...

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Main Authors: Seth, Shaguna, Vincent, Annelet, Compans, R. W.
格式: Artigo
語言:Inglês
出版: American Society for Microbiology 2003
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC140627/
https://ncbi.nlm.nih.gov/pubmed/12477822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.77.1.167-178.2003
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