A Potent Human Immunodeficiency Virus Type 1 Protease Inhibitor, UIC-94003 (TMC-126), and Selection of a Novel (A28S) Mutation in the Protease Active Site

We identified UIC-94003, a nonpeptidic human immunodeficiency virus (HIV) protease inhibitor (PI), containing 3(R),3a(S),6a(R)-bis-tetrahydrofuranyl urethane (bis-THF) and a sulfonamide isostere, which is extremely potent against a wide spectrum of HIV (50% inhibitory concentration, 0.0003 to 0.0005...

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Detalhes bibliográficos
Main Authors: Yoshimura, Kazuhisa, Kato, Ryohei, Kavlick, Mark F., Nguyen, Aline, Maroun, Victor, Maeda, Kenji, Hussain, Khaja A., Ghosh, Arun K., Gulnik, Sergei V., Erickson, John W., Mitsuya, Hiroaki
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2002
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC135775/
https://ncbi.nlm.nih.gov/pubmed/11773409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.76.3.1349-1358.2002
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