JE-2147: A dipeptide protease inhibitor (PI) that potently inhibits multi-PI-resistant HIV-1

We designed, synthesized, and identified JE-2147, an allophenylnorstatine-containing dipeptide HIV protease inhibitor (PI), which is potent against a wide spectrum of HIV-1, HIV-2, simian immunodeficiency virus, and various clinical HIV-1 strains in vitro. Drug-resistant clinical HIV-1 strains, isol...

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Detalhes bibliográficos
Main Authors: Yoshimura, Kazuhisa, Kato, Ryohei, Yusa, Keisuke, Kavlick, Mark F., Maroun, Victor, Nguyen, Aline, Mimoto, Tsutomu, Ueno, Takamasa, Shintani, Makoto, Falloon, Judith, Masur, Henry, Hayashi, Hideya, Erickson, John, Mitsuya, Hiroaki
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 1999
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC17575/
https://ncbi.nlm.nih.gov/pubmed/10411934
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