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Alternate exon insertion controls selective ubiquitination and degradation of different AUF1 protein isoforms

The A+U-rich element (ARE) in the 3′ non-coding region (3′ NCR) of short-lived cytokine mRNAs binds several regulatory proteins, including hnRNP D/AUF1, which comprises four isoforms of 37, 40, 42 and 45 kDa. ARE-mRNA degradation involves ubiquitin–proteasome activity, and one or more AUF1 proteins...

Whakaahuatanga katoa

I tiakina i:
Ngā taipitopito rārangi puna kōrero
I whakaputaina i:Nucleic Acids Res
Ngā kaituhi matua: Laroia, Gaurav, Schneider, Robert J.
Hōputu: Artigo
Reo:Inglês
I whakaputaina: Oxford University Press 2002
Ngā marau:
Urunga tuihono:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC135764/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12136087/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/gkf444
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