MAGI-1 Is Required for Rap1 Activation upon Cell-Cell Contact and for Enhancement of Vascular Endothelial Cadherin-mediated Cell Adhesion

Rap1 is a small GTPase that regulates adherens junction maturation. It remains elusive how Rap1 is activated upon cell-cell contact. We demonstrate for the first time that Rap1 is activated upon homophilic engagement of vascular endothelial cadherin (VE-cadherin) at the cell-cell contacts in living...

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Hlavní autoři: Sakurai, Atsuko, Fukuhara, Shigetomo, Yamagishi, Akiko, Sako, Keisuke, Kamioka, Yuji, Masuda, Michitaka, Nakaoka, Yoshikazu, Mochizuki, Naoki
Médium: Artigo
Jazyk:Inglês
Vydáno: The American Society for Cell Biology 2006
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1356604/
https://ncbi.nlm.nih.gov/pubmed/16339077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E05-07-0647
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