Cyclic AMP Potentiates Vascular Endothelial Cadherin-Mediated Cell-Cell Contact To Enhance Endothelial Barrier Function through an Epac-Rap1 Signaling Pathway

Cyclic AMP (cAMP) is a well-known intracellular signaling molecule improving barrier function in vascular endothelial cells. Here, we delineate a novel cAMP-triggered signal that regulates the barrier function. We found that cAMP-elevating reagents, prostacyclin and forskolin, decreased cell permeab...

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Autores principales: Fukuhara, Shigetomo, Sakurai, Atsuko, Sano, Hideto, Yamagishi, Akiko, Somekawa, Satoshi, Takakura, Nobuyuki, Saito, Yoshihiko, Kangawa, Kenji, Mochizuki, Naoki
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2005
Materias:
Signal Transduction
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC538793/
https://ncbi.nlm.nih.gov/pubmed/15601837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.1.136-146.2005
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