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MLL-AFX Requires the Transcriptional Effector Domains of AFX To Transform Myeloid Progenitors and Transdominantly Interfere with Forkhead Protein Function
MLL-AFX is a fusion gene created by t(X;11) chromosomal translocations in a subset of acute leukemias of either myeloid or lymphoid derivation. It codes for a chimeric protein consisting of MLL fused to AFX, a forkhead transcription factor that normally regulates genes involved in apoptosis and cell...
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| Hlavní autoři: | , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
American Society for Microbiology
2002
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| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC135648/ https://ncbi.nlm.nih.gov/pubmed/12192052 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.18.6542-6552.2002 |
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