MLL-AFX Requires the Transcriptional Effector Domains of AFX To Transform Myeloid Progenitors and Transdominantly Interfere with Forkhead Protein Function

MLL-AFX is a fusion gene created by t(X;11) chromosomal translocations in a subset of acute leukemias of either myeloid or lymphoid derivation. It codes for a chimeric protein consisting of MLL fused to AFX, a forkhead transcription factor that normally regulates genes involved in apoptosis and cell...

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Publié dans:	Mol Cell Biol
Auteurs principaux:	So, Chi Wai, Cleary, Michael L.
Format:	Artigo
Langue:	Inglês
Publié:	Taylor & Francis 2002
Sujets:	Transcriptional Regulation
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC135648/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12192052/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.22.18.6542-6552.2002
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