Interplay between 7SK snRNA and oppositely charged regions in HEXIM1 direct the inhibition of P-TEFb

Transcription elongation of eukaryotic genes by RNA polymerase II depends on the positive transcription elongation factor b (P-TEFb). When sequestered into the large complex, P-TEFb kinase activity is inhibited by the coordinate actions of 7SK small nuclear RNA (7SK snRNA) and hexamethylene bisaceta...

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Bibliografiske detaljer
Main Authors: Barboric, Matjaz, Kohoutek, Jiří, Price, Jason P, Blazek, Dalibor, Price, David H, Peterlin, B Matija
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2005
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1356324/
https://ncbi.nlm.nih.gov/pubmed/16362050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600883
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