Chaperone Proteins Abrogate Inhibition of the Human Papillomavirus (HPV) E1 Replicative Helicase by the HPV E2 Protein

Human papillomavirus (HPV) DNA replication requires the viral origin recognition protein E2 and the presumptive viral replicative helicase E1. We now report for the first time efficient DNA unwinding by a purified HPV E1 protein. Unwinding depends on a supercoiled DNA substrate, topoisomerase I, sin...

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Bibliographische Detailangaben
Hauptverfasser: Lin, Biing Yuan, Makhov, Alexander M., Griffith, Jack D., Broker, Thomas R., Chow, Louise T.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2002
Schlagworte:
DNA Dynamics and Chromosome Structure
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC135630/
https://ncbi.nlm.nih.gov/pubmed/12192057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.18.6592-6604.2002
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