The SMN Complex Is Associated with snRNPs throughout Their Cytoplasmic Assembly Pathway

The common neurodegenerative disease spinal muscular atrophy is caused by reduced levels of the survival of motor neurons (SMN) protein. SMN associates with several proteins (Gemin2 to Gemin6) to form a large complex which is found both in the cytoplasm and in the nucleus. The SMN complex functions...

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Bibliographic Details
Main Authors: Massenet, Séverine, Pellizzoni, Livio, Paushkin, Sergey, Mattaj, Iain W., Dreyfuss, Gideon
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2002
Subjects:
Gene Expression
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC135628/
https://ncbi.nlm.nih.gov/pubmed/12192051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.18.6533-6541.2002
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