Hypoxia Links ATR and p53 through Replication Arrest

Previous studies have demonstrated that phosphorylation of human p53 on serine 15 contributes to protein stabilization after DNA damage and that this is mediated by the ATM family of kinases. However, cellular exposure to hypoxia does not induce any detectable level of DNA lesions compared to ionizi...

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Detalhes bibliográficos
Main Authors: Hammond, Ester M., Denko, Nicholas C., Dorie, Mary Jo, Abraham, Robert T., Giaccia, Amato J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2002
Assuntos:
DNA Dynamics and Chromosome Structure
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC135616/
https://ncbi.nlm.nih.gov/pubmed/11865061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.6.1834-1843.2002
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