Hypoxia Links ATR and p53 through Replication Arrest

Previous studies have demonstrated that phosphorylation of human p53 on serine 15 contributes to protein stabilization after DNA damage and that this is mediated by the ATM family of kinases. However, cellular exposure to hypoxia does not induce any detectable level of DNA lesions compared to ionizi...

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Hlavní autoři: Hammond, Ester M., Denko, Nicholas C., Dorie, Mary Jo, Abraham, Robert T., Giaccia, Amato J.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2002
Témata:
DNA Dynamics and Chromosome Structure
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC135616/
https://ncbi.nlm.nih.gov/pubmed/11865061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.6.1834-1843.2002
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