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Tumor suppression and normal aging in mice with constitutively high p53 activity
The p53 inhibitor murine double-minute gene 2 (Mdm2) is a target for potential cancer therapies, however increased p53 function can be lethal. To directly address whether reduced Mdm2 function can inhibit tumorigenesis without causing detrimental side effects, we exploited a hypomorphic murine allel...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1356096/ https://ncbi.nlm.nih.gov/pubmed/16391230 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1378506 |
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