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Fe(2+)-Tetracycline-Mediated Cleavage of the Tn10 Tetracycline Efflux Protein TetA Reveals a Substrate Binding Site near Glutamine 225 in Transmembrane Helix 7

TetA specified by Tn10 is a class B member of a group of related bacterial transport proteins of 12 transmembrane alpha helices that mediate resistance to the antibiotic tetracycline. A tetracycline-divalent metal cation complex is expelled from the cell in exchange for a entering proton. The site(s...

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Autori principali: McMurry, Laura M., Aldema-Ramos, Mila L., Levy, Stuart B.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2002
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC135328/
https://ncbi.nlm.nih.gov/pubmed/12193628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.184.18.5113-5120.2002
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