Fe(2+)-Tetracycline-Mediated Cleavage of the Tn10 Tetracycline Efflux Protein TetA Reveals a Substrate Binding Site near Glutamine 225 in Transmembrane Helix 7

TetA specified by Tn10 is a class B member of a group of related bacterial transport proteins of 12 transmembrane alpha helices that mediate resistance to the antibiotic tetracycline. A tetracycline-divalent metal cation complex is expelled from the cell in exchange for a entering proton. The site(s...

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Bibliografiske detaljer

Udgivet i:	J Bacteriol
Principais autores:	McMurry, Laura M., Aldema-Ramos, Mila L., Levy, Stuart B.
Format:	Artigo
Sprog:	Inglês
Udgivet:	American Society for Microbiology (ASM) 2002
Fag:	Microbial Cell Biology
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC135328/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12193628/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JB.184.18.5113-5120.2002
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