Mitochondrial aldehyde dehydrogenase-2 (ALDH2) Glu504Lys polymorphism contributes to the variation in efficacy of sublingual nitroglycerin

Glyceryl trinitrate (GTN), also known as nitroglycerin, has been used to treat angina and heart failure for more than 130 years. Recently, it was shown that mitochondrial aldehyde dehydrogenase-2 (ALDH2) is responsible for formation of NO, the metabolite needed for GTN efficacy. In the present study...

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Hoofdauteurs: Li, Yifeng, Zhang, Dandan, Jin, Wei, Shao, Chunhong, Yan, Pengrong, Xu, Congjian, Sheng, Haihui, Liu, Yan, Yu, Jinde, Xie, Yuying, Zhao, Yingnan, Lu, Daru, Nebert, Daniel W., Harrison, Donald C., Huang, Wei, Jin, Li
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Clinical Investigation 2006
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1351000/
https://ncbi.nlm.nih.gov/pubmed/16440063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI26564
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