Mitochondrial aldehyde dehydrogenase-2 (ALDH2) Glu504Lys polymorphism contributes to the variation in efficacy of sublingual nitroglycerin

Glyceryl trinitrate (GTN), also known as nitroglycerin, has been used to treat angina and heart failure for more than 130 years. Recently, it was shown that mitochondrial aldehyde dehydrogenase-2 (ALDH2) is responsible for formation of NO, the metabolite needed for GTN efficacy. In the present study...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Li, Yifeng, Zhang, Dandan, Jin, Wei, Shao, Chunhong, Yan, Pengrong, Xu, Congjian, Sheng, Haihui, Liu, Yan, Yu, Jinde, Xie, Yuying, Zhao, Yingnan, Lu, Daru, Nebert, Daniel W., Harrison, Donald C., Huang, Wei, Jin, Li
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Clinical Investigation 2006
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC1351000/
https://ncbi.nlm.nih.gov/pubmed/16440063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI26564
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg