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Stable Growth of Wild-Type Hepatitis A Virus in Cell Culture

Human wild-type (wt) hepatitis A virus (HAV), the causative agent of acute hepatitis, barely grows in cell culture and in the process accumulates attenuating and cell culture-adapting mutations. This genetic instability of wt HAV in cell culture is a major roadblock to studying HAV pathogenesis and...

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Bibliografske podrobnosti
Main Authors: Konduru, Krishnamurthy, Kaplan, Gerardo G.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2006
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1346922/
https://ncbi.nlm.nih.gov/pubmed/16415012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.80.3.1352-1360.2006
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