Determinants in 3D(pol) Modulate the Rate of Growth of Hepatitis A Virus

Hepatitis A virus (HAV), an atypical member of the Picornaviridae, grows poorly in cell culture. To define determinants of HAV growth, we introduced a blasticidin (Bsd) resistance gene into the virus genome and selected variants that grew at high concentrations of Bsd. The mutants grew fast and had...

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Detalhes bibliográficos
Main Authors: Konduru, Krishnamurthy, Kaplan, Gerardo G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2010
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2916523/
https://ncbi.nlm.nih.gov/pubmed/20534860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01470-09
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https://ncbi.nlm.nih.gov/pmc/articles/PMC2916523/
https://ncbi.nlm.nih.gov/pubmed/20534860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01470-09