Determinants in 3D(pol) Modulate the Rate of Growth of Hepatitis A Virus
Hepatitis A virus (HAV), an atypical member of the Picornaviridae, grows poorly in cell culture. To define determinants of HAV growth, we introduced a blasticidin (Bsd) resistance gene into the virus genome and selected variants that grew at high concentrations of Bsd. The mutants grew fast and had...
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Main Authors: | , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
American Society for Microbiology (ASM)
2010
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Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2916523/ https://ncbi.nlm.nih.gov/pubmed/20534860 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01470-09 |
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