Lethal Action of Quinolones against a Temperature-Sensitive dnaB Replication Mutant of Escherichia coli

Inhibition of DNA replication in an Escherichia coli dnaB-22 mutant failed to block quinolone-mediated lethality. Inhibition of protein synthesis by chloramphenicol inhibited nalidixic acid lethality and, to a lesser extent, ciprofloxacin lethality in both dnaB-22 and wild-type cells. Thus, major fe...

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Bibliographic Details
Main Authors: Zhao, Xilin, Malik, Muhammad, Chan, Nymph, Drlica-Wagner, Alex, Wang, Jian-Ying, Li, Xinying, Drlica, Karl
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2006
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Mechanisms of Action: Physiological Effects
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1346826/
https://ncbi.nlm.nih.gov/pubmed/16377712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.50.1.362-364.2006
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