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Lon Protease Is Essential for Paradoxical Survival of Escherichia coli Exposed to High Concentrations of Quinolone

A deficiency of the Escherichia coli Lon protease blocked paradoxical survival occurring at very high nalidixic acid concentrations. The absence of Lon also blocked a parallel increase in cell lysate viscosity likely to reflect DNA size. Thus, Lon may participate in repairing quinolone-mediated DNA...

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Detalhes bibliográficos
Main Authors: Malik, Muhammad, Capecci, Joseph, Drlica, Karl
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2704693/
https://ncbi.nlm.nih.gov/pubmed/19414573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00019-09
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