IdeS, a Highly Specific Immunoglobulin G (IgG)-Cleaving Enzyme from Streptococcus pyogenes, Is Inhibited by Specific IgG Antibodies Generated during Infection

IdeS, a recently discovered cysteine proteinase secreted by the important human pathogen Streptococcus pyogenes, interferes with phagocytic killing by specifically cleaving the heavy chain of immunoglobulin G. The fact that the enzyme targets one of the key molecules of the adapted immune response r...

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Detalhes bibliográficos
Main Authors: Åkesson, Per, Moritz, Linnea, Truedsson, Mikael, Christensson, Bertil, von Pawel-Rammingen, Ulrich
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2006
Assuntos:
Host Response and Inflammation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1346671/
https://ncbi.nlm.nih.gov/pubmed/16369006
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.74.1.497-503.2006
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