Adoptive Immunotherapy against Experimental Visceral Leishmaniasis with CD8(+) T Cells Requires the Presence of Cognate Antigen

CD8(+) T cells have a protective role in experimental visceral leishmaniasis. However, the observation that inflammatory cytokines induce bystander activation of CD8(+) T cells questions the need for antigen-dependent effector function. Here, we demonstrate that successful adoptive immunotherapy wit...

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Detalhes bibliográficos
Main Authors: Polley, Rosalind, Stager, Simona, Prickett, Sara, Maroof, Asher, Zubairi, Soombul, Smith, Deborah F., Kaye, Paul M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2006
Assuntos:
Fungal and Parasitic Infections
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1346645/
https://ncbi.nlm.nih.gov/pubmed/16369038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.74.1.773-776.2006
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