Molecular Mechanism of Insulin-Induced Degradation of Insulin Receptor Substrate 1

Insulin receptor substrate 1 (IRS-1) plays an important role in the insulin signaling cascade. In vitro and in vivo studies from many investigators have suggested that lowering of IRS-1 cellular levels may be a mechanism of disordered insulin action (so-called insulin resistance). We previously repo...

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Hlavní autoři: Zhande, Rachel, Mitchell, John J., Wu, Jiong, Sun, Xiao Jian
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2002
Témata:
Cell Growth and Development
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC134643/
https://ncbi.nlm.nih.gov/pubmed/11809794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.4.1016-1026.2002
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